USMLE Step 1
Pass/Fail Course
Be ready on test day with HyGuru’s comprehensive USMLE Step 1 course.
Learn. Integrate. Apply.
Mapped to Step 1 Content Outline
This course strategically addresses all of the most heavily tested subjects on Step 1 and teaches you how they will appear
Content and Question Review at the Same Time
Do content review and Step 1 questions in addition to hundreds of active recall questions in every HyGuru lecture.
One Single Resource
This course is all you need. Stop reading and highlighting a million resources. Integrate medical content across organ systems and into practice questions right from the start.
About This Course
Mapped to the USMLE content outline, HyGuru's comprehensive USMLE Step 1 course augments the pathophysiology in the free NBME Top Concepts with the relevant physiology and pharmacology. Integrated with immunology and biochemistry, this course provides a high-yield, integrative overview of each organ system. Further differentiating it from the free NBME Top Concepts Course are the following elements:
- Genera Pathology from Pathoma chapters 1-3 with vignette flashcards
- Genetics and Syndromes
- Rapid Review from First Aid on all organ systems
- Acid-Base Physiology
- Antimicrobials
- Ethics
- Additional High Yield Images and PE Findings lectures
No more rote memorization – optimize your understanding
Learning the clinical application of medical facts is critical to success on Step 1 and as a doctor. With Rahul, you’ll learn pathology, biochemistry, physiology, and pharmacology but in an integrated manner. You’ll appreciate the interconnectedness and practical application of these disciplines right from the beginning.
Think like the test maker
Rahul takes you into the head of the test maker early and often by presenting material as it appears within real Step 1 questions. By doing hundreds of USMLE questions within Rahul’s lectures, you’ll learn common testing patterns and question structures all while mastering content. By test day, you’ll be Thinking like the Test Maker.
Components of this course include:
Organs Systems Rapid Review & NBME Top Concepts
All of the isolated facts from First Aid’s Rapid Review presented in an integrated, organ systems based, active recall method; a bonus section on the most commonly tested clinical triads.
Physiology
Top concepts across all organ systems from BRS Costanzo, integrated and presented in active recall manner.
Pharmacology
Lectures take you beyond drug memorization to understanding the mechanism of action and target pathophysiology as well as USMLE application.
Pathology
General pathology concepts from Pathoma chapters 1-3 applied clinically and across organ systems.
Biochemical Pathways & Metabolism
High yield lectures dedicated to metabolic pathways and their most common USMLE applications. Also contains Genetics and Syndromes.
100 Concepts in Gross Anatomy
Most easily and frequently forgotten section of medical education re-presented in a clinically integrated format. 100 of the highest yield anatomy concepts and their clinical correlates.
Ethics & Physician Communication
Lectures dedicated to reflect Oct/Nov 2020 changes to the USMLE.
Immunology
Review relevant, testable details related to the innate and adaptive immune response. Master immunology in an active-recall manner with vignettes highlighting key pathology correlates.
High Yield Images
Over 20% of USMLE questions on exam day will have multi-media images for you to interpret. Be prepared with unique gross, microscopic, and radiographic correlates and their vignettes.
Curriculum
Welcome to the HyGuru USMLE Step 1 Pass Fail Course
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Course Notes
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USMLE Step 1 General Pathology Active Recall Review [Pathoma Ch 1-3]
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- General Pathology Active Recall Review [Pathoma Ch 1-3] - PDF Handout
- General Pathology (Pathoma Ch 1-3) Webinar Handout
- Cell Injury, Death, and Adaptations (38:52)
- Necrosis (11:29)
- Apoptosis (9:05)
- Free Radical Injury and Amyloid (11:34)
- Acute Inflammation (24:16)
- Chronic Inflammation (7:15)
- Immunodeficiency (3:52)
- Neoplasia (12:15)
- Grading vs. Staging (1:26)
- Closing Thoughts & Study Outline (2:52)
Top USMLE Concepts in Immunology
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- Top USMLE Concepts in Immunology - PDF Handout
- Introduction to Immunology for the USMLE (10:19)
- Innate Immunity (13:29)
- Mucosal Immunity (7:02)
- Respiratory Immunity (7:04)
- Salmonella Typhi (Micro Integration) (4:46)
- Anatomic Barriers (2:45)
- TLR & PAMPs (5:08)
- Phagocytes (2:51)
- Tuberculosis (Micro Integration) (18:46)
- NK Cells (2:23)
- MHC & HLA (3:03)
- ✚➖ selection (6:02)
- MHC 1 vs. MHC 2 (9:28)
- Autoimmune Diseases (2:16)
- Addison’s & Aldosterone Escape (11:17)
- Pernicious Anemia (2:45)
- Hashimoto’s Thyroiditis (3:23)
- Systemic Autoimmune Conditions (2:07)
- Organ System Specific Autoimmune Conditions (15:52)
- Acute Inflammation (3:50)
- Edema & Inflammation (14:12)
- Neutrophil Migration (5:54)
- Phagocytosis & ROS burst (8:51)
- Summary of Inflammation (6:19)
- Complications of Acute Inflammation (2:46)
- Wound Healing (7:28)
- Delayed Wound Healing (6:21)
- Spleen (10:11)
- Splenomegaly (4:58)
- Asplenia (4:09)
- BM & Thymus (5:52)
- Lymph Node (10:49)
- Intro to Lymph Drainage (4:55)
- Palpable Lymph Nodes (21:42)
- Deep Lymph Nodes (10:06)
- Adaptive Immune Response (5:16)
- TSST Integration (4:25)
- T cell Activation & Differentiation (7:49)
- B cell Activation & Ig (8:14)
- Immunodeficiencies (26:08)
- Complement Disorders (9:41)
- Introduction to Transplant Immunology (1:25)
- Hyperacute Transplant Rejection (1:58)
- Chronic Transplant Rejection (3:42)
- Acute Transplant Rejection (1:52)
- Graft Versus Host Disease (2:32)
- Cytokines for the USMLE (6:06)
- Eosinophilia (2:02)
- Vaccines (10:37)
- MHC (0:44)
- COVID & Live Vaccines (4:48)
- Immunoglobulins (5:56)
- Key Immunology Details (1:16)
HyGuru Immunology for the USMLE: Hypersensitivity
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- HyGuru Immunology for the USMLE: Hypersensitivity - PDF Handout
- Type 1 Hypersensitivity (12:08)
- Asthma (3:59)
- Pharmacology Integration (7:48)
- Shock Integration (5:10)
- Type 2 Hypersensitivity (15:12)
- Endocrine Integration (2:59)
- Hematology Integration (7:57)
- Type 3 Hypersensitivity (8:08)
- Type 4 Hypersensitivity (5:10)
- General Pathology Integration (2:38)
- Summary (0:22)
USMLE Step 1 Biochemistry & Metabolism Review
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- USMLE Step 1 Biochemistry & Metabolism - PDF Handout
- Introduction (19:50)
- Basics of Metabolism (4:28)
- Enzyme Terminology (5:59)
- Transamination Reactions (AST/ALT) (3:30)
- Dehydrogenase Enzymes (6:27)
- Overview of Metabolism for the USMLE (1:32)
- Glycolysis (13:10)
- Gluconeogenesis (11:50)
- Metabolic Regulation of Pyruvate (1:45)
- Ethanol Metabolism (3:30)
- Glycogen Storage Diseases (6:59)
- Fructose, Galactose, Lactose (14:18)
- Lipid Metabolism & Synthesis (10:19)
- Fatty Acid Oxidation (8:24)
- Odd Chain FA Metabolism (7:32)
- B12 Deficiency Integration (2:39)
- Summary of Lipids (1:02)
- Ketone Metabolism (4:59)
- DKA (Integration) (6:33)
- Amino Acid Metabolism (9:46)
- Urea Cycle (8:23)
- Collagen Synthesis (5:04)
- Energy Production (9:37)
- TCA Cycle (5:10)
- Electron Transport Chain (20:38)
- Uncoupling Agents (17:03)
- Cholesterol & Lipid Metabolism (9:58)
- VLDL (5:02)
- IDL (2:26)
- LDL & Atherosclerosis (5:30)
- HDL (4:30)
- Lipid Disorders for the USMLE (11:32)
- HMP Shunt Pathway (9:19)
- Nucleotide Synthesis (3:07)
- Biochemistry of Nutrition (2:56)
- Fat Soluble Vitamins (6:53)
- Cystic Fibrosis (5:05)
- Water Soluble Vitamins (12:27)
- Approach to Pedigrees on the USMLE (15:18)
- Lysosomal Storage Diseases (2:52)
- Summary of Biochemical Pathways (6:11)
- Chromosome Abnormalities for the USMLE (8:17)
DNA Synthesis, Transcription, Translation (USMLE Step 1)
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- DNA Synthesis, Transcription, Translation Handout
- Session Outline (5:17)
- Sites of Metabolism (3:14)
- DNA Rapid Review (1:33)
- HMP Shunt Nucleotide Synthesis (6:28)
- DNA Replication (2:40)
- Telomerase & Topoisomerase (4:44)
- DNA Polymera & Synthesis (4:12)
- Transcription (2:12)
- Steroid hormones (8:42)
- Lac Operon (4:35)
- Transcription revisited (4:36)
- Splicing and Post Transcriptional_Modifications (1:22)
- Spinal Muscular Atrophy Integration (7:01)
- Translation (1:02)
- tRNA structure significance (3:30)
- Prokaryotic vs Eukaryoti translation (8:08)
- Protein Elongation Virulence Factor Integration (4:31)
- Trnaslocation (3:16)
- Post Translational Modification (4:10)
- I Cell disease Integration (1:10)
- Summary (0:23)
Genetic Principles & Hardy Weinberg
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- Introduction (1:43)
- Overview (2:24)
- Session Outline (3:17)
- Multi-Organ Dysfunction (1:50)
- Co Dominance (4:21)
- Genotype vs Phenotype (1:10)
- Variable Expressivity vs Pleiotropy (1:41)
- Neurofibromatosis (7:26)
- Anticipation (3:54)
- USMLE Trinucleotide Repeats (4:57)
- Mosaicism (1:39)
- Imprinting Disorder (6:31)
- Linkage Disequilibrium (5:19)
- Test Taking Strategy for USMLE (5:43)
- Pedigrees (6:55)
USMLE Step 1 — Metabolic and Genetic Syndromes
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- USMLE Step 1 — Metabolic and Genetic Syndromes - PDF Handout
- Introduction (2:32)
- A Test Taking Approach for Syndromes (5:28)
- Down's Syndrome Integration (15:18)
- Patau & Edwards Syndrome (2:39)
- Imprinting Syndromes (5:01)
- Homocystinuria (4:09)
- Marfanoid Habitus (8:30)
- Marfan’s Syndrome (1:36)
- Ehler’s Danlos Syndrome (2:17)
- Lesch Nyhan Syndrome (3:16)
- Kartagener’s Syndrome (4:31)
- Cystic Fibrosis (8:00)
- Neurocutaneous Syndromes (3:00)
- Lupus Integration (9:29)
High Yield Images & PE for the USMLE Step 1 (Introduction)
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Foundations of Physiology for the USMLE (Cardiology)
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- Foundations of Physiology for the USMLE (Cardiology) - PDF Handout
- Introduction (2:48)
- Cardiac Cycle (8:09)
- Isovolumetric Ventricular Contraction (2:38)
- Rapid Ventricular Ejection (5:42)
- Isovolumetric Ventricular Relaxation (3:11)
- Ventricular Filling (9:39)
- Atrial Systole (5:20)
- Jugular Venous Tracing (5:03)
- Pulsus Paradoxes (3:25)
- Pressure Volume Loops (17:00)
- Cardiac Action Potentials (6:04)
Integrative Microbiology (Cardiology)
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Integrated Microbiology for the USMLE | Cardiology
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- Overview (10:30)
- Hyperthermia (1:45)
- Immunocompromised Host for USMLE (2:04)
- Acute Inflammation for USMLE (5:58)
- Cardiac Microbiology (2:10)
- Pathophysiology of Sub-Acute Bacterial Endocarditis (0:46)
- Bacteria Biofilms (3:47)
- Viridans Streptococci (1:22)
- Indications for Antimicrobial PPX for Endocarditis (1:11)
- Acute Bacterial Endocarditis (5:38)
- IV Drug Use and Endocarditis (1:51)
- Culture Positive Infective Endocarditis (2:46)
- Pathophysiology of Acute Rheumatic Fever (3:57)
- Group A Streptococcus (3:15)
- Scarlet vs Rheumatic Fever (2:38)
- Jones Criteria for USMLE (3:59)
- Heart Block Lyme Disease (4:14)
- Mitral Stenosis (2:41)
- Staph and Strep Morphology Summary (3:00)
- Diphtheria (2:51)
- Protein Synthesis Inhibition (2:46)
- Myocarditis (1:00)
NBME Top Concepts: Cardiology
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High Yield USMLE Images & PE Findings: Cardiology
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- Course Overview (1:00)
- Right Heart Failure vs. Left Heart Failure (5:48)
- Murmurs & Maneuvers (25:15)
- Transudative vs. Exudative for the USMLE (1:29)
- Mechanisms of Edema (3:17)
- X-Rays of Cardiac Lesions (0:29)
- Turner Syndrome (2:45)
- Rapid Review Genetic Heart Lesions & Cardiac Anomalies (2:02)
- Genetic Conditions & Heart Lesions (0:53)
- Pathophysiology of Tetralogy of Fallot (3:33)
- Pathophysiology of Tet Spells (2:44)
- Endocarditis (4:05)
- Microbiology Integration (3:12)
- Infective Endocarditis on USMLE (3:17)
- Rheumatic Fever (6:09)
- Erythema Marginatam (1:18)
Integrative Classroom Cases: Cardiology
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- Integrative Classroom Case: Septal Defects (9:21)
- Integrative Classroom Case: Fetal Circulation (3:10)
- Integrative Classroom Case: Murmurs (8:19)
- Integrative Classroom Case: Arrhythmias (16:07)
- Integrative Classroom Case: Amyloid & Carotid Hypersensitivity (2:30)
- Integrative Classroom Case: Congenital Heart Defects (2:56)
- Integrative Classroom Case: Dyslipidemia & Myocardial Infarction (19:45)
- Integrative Classroom Case: Endocarditis, Myocarditis, Pericarditis (18:30)
- Integrative Classroom Case: Chest Pain, Cardiomyopathies, & CHF (11:24)
An Introduction to Mechanisms of Pharmacology
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Mechanisms of Pharmacology (Cardiology)
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- Mechanisms of Pharmacology (Cardiology) - PDF Handout
- Introduction to Cardiac Pharm (0:54)
- Atrial Fibrillation & Virchow’s Triad (6:40)
- Rate Control vs. Rhythm Control (3:00)
- Anti-Arrhythmic Medications (Intro) (2:55)
- Amiodarone Systemic Toxicity (3:09)
- Cardiac Action Potentials (6:13)
- Class 1 Anti-Arrhythmics (4:14)
- Drug Induced Lupus Integration (2:08)
- Class 2 Anti-Arrhythmics (Integrates MVO2) (7:20)
- Calcium Channel Blockers (6:57)
- Summary of Anti-Arrhythmics (1:22)
- Introduction to Heart Failure (RAAS) (11:14)
- Acute Heart Failure Pharmacology (4:05)
- Chronic Heart Failure Pharmacology (3:38)
- Digoxin (Toxicity) (4:50)
- Anti-Lipid Agents (9:36)
- LDL, HDL, TAG, Niacin (2:47)
- Fat Soluble Vitamins (integration) (4:58)
Foundations of Physiology for the USMLE (Endocrine)
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Integrative Microbiology (Endocrine)
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NBME Top Concepts: Endocrine
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- Introduction (5:53)
- Lecture Preview (1:25)
- Hormone Signaling (9:46)
- Thyroid Disorders (7:38)
- Hypothyroid (6:06)
- Hyperthyroid (9:45)
- PTH and Calcium (9:57)
- MEN Syndromes (6:29)
- Islet Cell Tumors (3:33)
- DKA vs. HHS (6:27)
- Diabetes Pharmacology (4:55)
- Aldosterone Disorders (3:12)
- Conclusion (2:12)
- Endocrine: Thyroid Disorders (15:44)
- Integrative Classroom Case: Adrenal Disorders (19:16)
Mechanisms of Pharmacology (Endocrine)
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Mechanisms of Pharmacology (ANS)
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First Aid Rapid Review for the USMLE (Cardio, Endo, ANS)
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Foundations of USMLE Physiology (Renal)
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Integrative Microbiology (Renal)
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Integrated Microbiology for the USMLE | Renal
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- Overview of Session (0:58)
- Renal Microbiology for USMLE (4:05)
- Acute Cystitis (3:47)
- Renal Physiology Integration (4:44)
- Enterococcus for USMLE (4:05)
- Acute Interstitial Nephritis (0:46)
- Sterile Pyruia for USMLE (3:54)
- Pathophysiology of UTI (8:19)
- UTI Microbiology for USMLE (4:19)
- Medications for UTI in Pregnancy (1:40)
- Pregnancy Physiology Integration (4:51)
- Staghorn Calculus & Kidney Stones (3:07)
- Cystitis vs Pyelonephritis (3:09)
- Micturition Autonomic Integration (4:16)
- Urinary Tract Histology Integration (1:25)
- Squamous Cell Carcinoma of Bladder (3:33)
- Adenovirus for USMLE (2:50)
- Prostatitis for USMLE (0:57)
- Summary (3:59)
Top NBME Concepts: Renal
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High Yield USMLE Images & PE Findings: Renal
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Integrative Classroom Cases: Renal
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Mechanisms of Pharmacology (Renal)
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NBME Top Concepts: Acid Base
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Integrative Microbiology (Reproductive)
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Integrated Microbiology for the USMLE (Reproductive)
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- Introduction (1:43)
- Integrated Microbe Summary (1:31)
- Neonatal Infections (2:20)
- Neonatal Sepsis (6:53)
- TORCH infections (3:19)
- CMV (6:36)
- Pathophysiology of Failure To Thrive (4:41)
- HPV (4:47)
- Koliocytosis (3:16)
- Double Stranded DNA Viruses (3:31)
- P53 Pathophysiology (2:42)
- Sexually Transmitted Infections (5:21)
- Cervicitis & Urethritis (5:02)
- Chlamydia Integration (5:42)
- Reactive Arthritis (2:35)
- Sexually Transmitted Ulcers (7:54)
- PID Complications (2:56)
- Syphilis Manifestations (3:24)
Top NBME Concepts: Reproductive
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- Introduction (1:35)
- Disorders of Sexual Development (9:22)
- Turner’s Syndrome integration (9:49)
- Testosterone Disorders (3:48)
- Mullerian Agenesis vs. AIS (4:35)
- Summary of Disorders of Sexual Development (1:07)
- Polycystic Ovarian Syndrome (8:20)
- Ovarian Physiology (3:06)
- Ovarian Tumors (13:24)
- Repro Ligaments (2:40)
- Uterine Disorders (9:15)
- Cervical Disorders (HPV) (2:43)
- Integrative Classroom Case: Pharyngeal Arches (12:58)
- Integrative Classroom Case: Menstrual Cycle (10:40)
Mechanisms of Pharmacology (Reproductive)
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Foundations of USMLE Physiology (Gastrointestinal)
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Integrative Microbiology (Gastroenterology)
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Integrated Microbiology for the USMLE | Gastroenterology
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- Overview (1:13)
- Ulcers on the USMLE (6:16)
- Pathophysiology of H.Pylori (7:36)
- Oncogenic Microbes (1:25)
- Diarrhea (4:49)
- Viral Diarrhea (4:20)
- Protozoal Diarrhea (7:08)
- Guillain Barre Syndrome (1:37)
- Hemolytic Uremic Syndrome (5:19)
- Bacterial Causes of Bloody Diarrhea (4:10)
- Typhoidal Salmonella (0:43)
- Bacterial Causes of Non-bloody Diarrhea (6:52)
- Hepatitis B (14:59)
- Hep B vs Hep C (5:59)
NBME Top Concepts: Gastroenterology
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- Introduction (7:56)
- Esophageal Issues (12:00)
- Acid Secretion in Stomach (10:06)
- Approach to Abdominal Pain on the USMLE (10:30)
- Hernias (4:23)
- Meckel’s Diverticulum (4:10)
- Hirschsprung’s Disease (1:59)
- Inflammatory Bowel Disease (8:38)
- Bile Acid Metabolism (3:40)
- Hepatitis B (2:53)
- Vesicular Steatosis (5:15)
- Integrative Classroom Case: Peptic Ulcer Disease (6:35)
- Integrative Classroom Case: GERD, Hernias, & Esophageal Disorders (8:33)
High Yield USMLE Images & PE Findings: Gastroenterology
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Mechanisms of Pharmacology (Gastrointestinal)
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First Aid Rapid Review for the USMLE (Renal, Reproductive, Gastro)
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Neuroanatomy for the USMLE
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- Neuroanatomy Notes for the USMLE (PDF)
- Neuroanatomy Test Taking (3:00)
- Foramina of the Skull (15:39)
- Jugular Foramen (8:00)
- Chiari Malformations (4:19)
- Intro to Cranial Nerves (1:58)
- CN 1 | Olfactory (2:07)
- CN 2 | Optic (1:42)
- Pupillary Reflex (2:33)
- CN 3 | Oculomotor (4:41)
- CN 4 | Trochlear (1:54)
- CN 5 | Trigeminal (2:34)
- Jaw Jerk & Corneal Reflex (2:56)
- Intranuclear Ophthalmoplegia (4:43)
- CN 6 | Abducens (3:26)
- CN 7 | Facial (4:16)
- Tongue Innervation (5:05)
- CN 8 | Vestibulocochlear (5:03)
- CN 9 | Glossopharyngeal (3:34)
- CN 10 Vagus (7:56)
- CN 11 | Spinal Accessory (2:44)
- CN 12 | Hypoglossal (3:56)
- Medial vs Lateral Medullary syndrome (1:21)
- Pontine Strokes (4:18)
- Midbrain Strokes (3:44)
- Subclavian Steal (2:58)
- Optic Tracts (9:34)
- Eye Movements (3:18)
- Intro to Spinal Tracts (0:49)
- Dorsal Column (3:00)
- Corticospinal Tract (2:34)
- Spinothalamic Tract (2:53)
- Brown Sequard (2:45)
- Spinal Cord Lesions (8:09)
- Parkinson’s Disease (4:05)
- Alzheimer’s Disease (7:02)
- Summary of Neurotransmitters (2:32)
- Neural Tube & Brain Embryo (7:06)
- Hydrocephalus & Tumours (2:04)
- Gait Disorders (2:57)
- Hemiballismus (1:24)
- Deep Brain Strokes (9:01)
- Stroke Integration (9:44)
- Conclusion (1:58)
Integrative Microbiology (Neurology)
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Integrated Microbiology for the USMLE | Neurology
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- Introduction (4:13)
- Meningitis (8:31)
- Mechanisms of Bacterial CNS Infections (3:43)
- Temporal Lobe Abscess (7:51)
- Brain Abscess due to Infective Endocarditis (0:53)
- Neisseria Transmission (2:16)
- Waterhouse Friedrichsen Syndrome (4:53)
- Cyptoccal Infections (7:45)
- Summary of Bacterial Meningitis (6:18)
- Measles (1:06)
- Arbovirus (2:55)
- Echovirus (2:05)
- Coxsackie A (3:53)
- Ring Enhancin Brain Lesions for the USMLE (1:20)
- TORCH Infections for the USMLE (2:52)
- Pharmacology Integration (1:50)
- Prions (2:32)
- Summary (0:53)
NBME Top Concepts: Neurology
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- Introduction (2:06)
- Brain Hematomas (12:05)
- Herniation Syndromes & Cerebral Physiology (10:42)
- Cranial Nerve Path (1) (8:45)
- Bell’s Palsy (5:43)
- Cranial Nerve Path (2) (3:11)
- Multiple Sclerosis (5:22)
- Dementia (6:33)
- Dopamine Pathways (1:59)
- Trinucleotide Repeat Disorders (3:01)
- Neurocutaneous Syndromes (4:55)
- Brain Tumors (4:25)
- Stroke (6:40)
- Conclusion (3:32)
- Integrative Classroom Case: Cranial Nerves (7:22)
- Integrative Classroom Case: Aneurysms (8:21)
High Yield Images & PE Findings: Neurology
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- Overview (1:25)
- Neuroanatomy (1:43)
- Rapid Review of Trinucleotide Repeat Disorders (4:52)
- Pituitary Masses (1:53)
- Thalamic Stroke (2:32)
- Central Pontine Myelinolysis (4:36)
- Internal Capsule and Lacunar Strokes (5:26)
- Rapid Review of Multiple Sclerosis (3:04)
- Cerebral Edema (3:04)
- Intracranial Pressure (2:23)
- Rapid Review of Cerebral Autoregulation (2:25)
- Baroreceptor Reflex (7:43)
- Upper Motor Neuron Signs & Posturing (0:11)
- Spinal Cord Pathologies (12:07)
- Pseudotumor Cerebri (3:33)
- Hydrocephalus (5:47)
- CNS Infections (3:36)
Pharmacology of the Nervous System
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- Pharmacology of the Nervous System - PDF Handout
- Introduction (0:18)
- Anesthesia (20:37)
- Cerebral Autoregulation (Anesthesia) (6:00)
- GABA Drugs (5:20)
- Parkinson’s vs Alzheimer’s (2:44)
- Basal Ganglia Neuro-Anatomy integration (4:24)
- Parkinsonian Pharmacology [Dopamine] (9:20)
- Alzeihmer’s Drugs (7:26)
- NMDA Integration for the USMLE (1:26)
- Autonomic Pharmacology Integration (Ach) (2:54)
- AchE for Myasthenia Gravis (2:23)
100 Concepts in Gross Anatomy for the USMLE Step 1
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Integrative Microbiology (MSK)
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Top NBME Concepts: Dermatology
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- Overview (3:36)
- Approach to Urticaria (8:37)
- Dermatology Nomenclature (4:45)
- Plaques (3:51)
- Viral & Bacterial Exanthems (7:21)
- Rubella (3:01)
- Measles (2:39)
- Roseola (0:31)
- Erythema Infectiosum (5:05)
- Systemic Manifestations of Herpes (3:10)
- Varicella Infections on USMLE (2:00)
- Erysipelas vs Cellulitis (1:29)
- Staph and Strep Infections (2:57)
- Nikolsky Sign Manifestations for the USMLE (3:36)
- Neonatal Rashes (2:34)
- Precursor Lesions to Neoplasia (3:17)
- Summary (2:19)
Top NBME Concepts: Rheumatology
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- Introduction (2:45)
- NMJ Disorders (9:56)
- Bullous Diseases (5:33)
- Hemoptysis & Hematuria (7:34)
- Skin Cancers (with Neural Crest) (19:50)
- RA vs OA (12:49)
- Seronegative Spondyloarthritis (7:28)
- Lupus (8:03)
- Anti Body Rapid Fire (USMLE) (8:34)
- Integrative Classroom Case: Introduction to Dermatological Principles (6:22)
- Integrative Classroom Case: Fungal Rashes (7:49)
- Integrative Classroom Case: Collagen Disorders & Synthesis (7:02)
- Integrative Classroom Case: Bone Disorders
Top NBME Concepts: Psychiatry
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Psychopharmacology
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- Psychopharmacology - PDF Handout
- Introduction to Psychosis (2:08)
- Dopaminergic Pathways for the USMLE (1:29)
- Anti-Psychotics (3:08)
- Neuroleptic Malignant Syndrome (2:25)
- MH vs. NMS vs. SS [integration] (1:57)
- 1st Generation Antipsychotics (6:53)
- Rapid Review (1st generation) (1:46)
- 2nd Generation Anti-Psychotics (4:37)
- Agranulocytosis Medications (1:45)
- Anti-Depressants (Introduction) (2:21)
- Serotonin Syndrome (3:31)
- Anti-Depressants (Typical & Atypicals) (8:40)
- Tricyclic Anti-Depressants (5:00)
First Aid Rapid Review for the USMLE (Neuro, MSK, Derm, Rheum, Psych)
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Foundations of Physiology (Hematology)
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NBME Top Concepts: Hematology
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- Introduction (7:52)
- Lecture Preview (1:05)
- Heme Synthesis (5:40)
- CYP Inducers (3:47)
- Lead Poisoning (3:01)
- Approach to the Blood Smear (8:32)
- Intro to Anemia (3:07)
- Microcytic Anemia (5:01)
- Acute Phase Reactants (1:41)
- Summary of Microcytic (2:00)
- Macrocytic Anemia (5:14)
- B12 Physiology (1:30)
- Normocytic Anemia (6:58)
- HUS/TTP (2:57)
- Polycythemia (2:56)
- Platelet Pathology (5:33)
- Warfarin vs. Heparin (2:35)
- Multiple Myeloma (2:42)
- Summary & Courses (2:14)
- Integrative Classroom Case: Sickle Cell Disease (4:49)
- Neurology: Stroke (19:22)
High Yield Images & PE Findings: Hematology
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- Hematology Overview (2:14)
- Peripheral Blood Smear (8:47)
- RBC Inclusions (9:48)
- Sickle Cell Disease (12:33)
- Complications of Asplenia (3:44)
- Summary of RBC Inclusions (3:25)
- Mechanisms of Extravascular RBC Hemolysis (1:39)
- Mechanisms of Intravascular RBC Hemolysis (2:11)
- Rapid Review of Normocytic Anemia (7:45)
- Aplastic Anemia (11:40)
- Cold and Warm AIHA (0:51)
- HUS/TTP (1:42)
- Cells of the Immune System (2:17)
- Causes of Eosinophilia on USMLE (0:58)
- Causes of Plasma Cells on USMLE (2:33)
- Causes of Mast Cells on USMLE (2:22)
Mechanisms of Pharmacology (Hematology)
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- Mechanisms of Pharmacology (Hematology) - PDF Handout
- Hypercoagulable Pathology (integration) (5:12)
- Anti-coagulants (overview) (0:44)
- Primary Hemostasis Pharmacology (8:54)
- Secondary Hemostasis Pharmacology (Heparin vs. Warfarin) (3:47)
- Heparin Induced Thrombocytopenia (2:02)
- Direct Factor Inhibitors (4:06)
Foundations of Physiology (Respiratory)
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Integrative Microbiology (Respiratory)
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Integrative Microbiology for the USMLE (Respiratory)
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- Upper Respiratory Tract Disease (8:00)
- Influenza for the USMLE (7:43)
- Sinusitis for the USMLE (3:47)
- Pharyngeal Disease (5:47)
- Laryngotracheitis (3:03)
- Coxsackie AB is Picorna (PERCH) (7:38)
- Epiglottis for the USMLE (6:27)
- Pertussis for the USMLE (1:28)
- Lower RespiratoryTract Disease (3:32)
- Anatomic Distributions of PNA (2:20)
- Think Like a Test Maker (1:56)
- Bronchopneumonia (2:22)
- Mycoplasma for USMLE (8:11)
- Respiratory Microbes for the USMLE (2:26)
- S. Pneumoniae for the USMLE (3:44)
- Pathogenesis of TB (2:30)
- Recurrent Pneumonia for the USMLE (3:00)
- Pneumocystis for the USMLE (3:26)
Top NBME Concepts: Respiratory
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- Introduction (2:36)
- A-a gradient (hypoxemia) (23:45)
- Regional Circulation for the USMLE (11:43)
- Physical Exam MCQs (Resp) (9:03)
- Restrictive vs Obstructive Lung Disease (13:06)
- Lung Tumors (6:06)
- Acute Respiratory Distress Syndrome (6:12)
- Conclusion (0:23)
- Integrative Classroom Case: Hypoxemia (5:08)
- Integrative Classroom Case: Restrictive Lung Diseases & Pneumoconiosis (8:11)
- Integrative Classroom Case: Obstructive Lung Diseases (19:27)
High Yield USMLE Images & PE Findings: Respiratory
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Mechanisms of Pharmacology (Respiratory)
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- Mechanisms of Pharmacology (Respiratory) - PDF Handout
- Introduction (0:24)
- Pathophysiology of Asthma (4:36)
- β-Agonists (10:03)
- Systemic Toxicities of Corticosteroids (4:42)
- Anti-Leukotrienes & AA Pathway (1:50)
- Asthma Adjuncts (1:21)
- Pulmonary Hypertension Pathophysiology (6:18)
- Pulmonary Hypertension Pharmacology (2:22)
- Anti-Allergic Pharmacology (2:59)
First Aid Rapid Review for the USMLE (Heme, Resp, Embryo)
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Integrative Microbiology (Oncology)
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Top NBME Concepts: Oncology
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Chemotherapeutics & Immunologics
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Anti Microbials
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- Anti Microbials - PDF Handout
- Antibiotics PDF
- Beta-Lactam Introduction (9:22)
- Penicillins (6:43)
- Beta-Lactamase Sensitive Penicillin (12:21)
- Beta-Lactamase Resistant Penicillin (5:16)
- Antipseudomonal Penicillins (5:23)
- Key Bacterial Virulence Mechanisms (5:33)
- Cephalosporins (7:09)
- Broad Spectrum Antibiotics (4:30)
- Rapid Review (1:02)
- 30S Ribosomal Subunit Antibiotics (5:43)
- 50S Ribosomal Subunit Antibiotics (6:24)
- Resistance Mechanisms & Conclusion (5:18)
Integrative Microbiology (Zoonotic)
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USMLE Ethics, PBLI, Patient Safety & Physician Communication
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- USMLE Ethics, PBLI, Patient Safety & Physician Communication - PDF Handout
- Ethics, PBLI, Patient Safety & Physician Communication Handout
- Introduction to Ethics (5:36)
- Core Ethical Principles (48:37)
- Public Health Sciences (16:00)
- Nosocomial Infections (8:50)
- Patient Safety (18:02)
- Physician Communication (4:43)
High Yield Arrows for the USMLE ⬆️ ⬇️
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- High Yield Arrows for the USMLE - PDF Handout
- Overview of Arrow Questions (3:54)
- Cardiology System (1:23)
- Baroreceptor Reflex (7:51)
- Edema (2:36)
- Aldosterone Escape (3:04)
- Ventricular Septal Defect (3:05)
- Respiratory System (1:09)
- Chronic Respiratory Acidosis (3:10)
- Hypoxemia (5:10)
- Aging (1:36)
- Neonatal ARDS (2:05)
- Endocrine System (1:19)
- Adrenal Insufficiency (5:18)
- Waterhouse Friderichsen Syndrome (1:45)
- Hyperthyroidism (4:37)
- Euthyroid Sick Syndrome (1:49)
- Thyroid Binding Globulin (2:10)
- PTH effects on Bone Kidney and Intestine (4:40)
- Tertiary Hyper PTH (2:27)
- Albrights for the USMLE (4:23)
- Vitamin D Metabolism (2:38)
- Paget Diseases for USMLE (1:55)
- Reproductive System (1:04)
- Two Cell Hypothesis (7:08)
- Renal System (3:24)
- Nephron Key Features (9:14)
- Afferent vs Efferent Arteriole (2:56)
- Renin Angiotensin Aldosterone System (1:59)
- Primary vs Secondary Hemostasis (3:50)
Integrated Embryology for the USMLE Step 1
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- Introduction (4:45)
- Session Outline (2:24)
- Neural Tube Defects (2:48)
- Potter Sequence (2:41)
- Amniotic Fluid Integration (2:41)
- Trilaminar Structure Derivation (6:28)
- GI Embryology & Histology Integration (4:35)
- Neural Crest Derivatives (6:55)
- DiGeorge Syndrome (5:22)
- Genital Organ Differentiation (4:52)
- Atresia for the USMLE (5:43)
- Umbilical Cord Embryology (3:06)
- Renal Embryology (5:12)
- ENT Embryology (4:41)
- Embryology Rapid Review (3:25)
Key Vignettes for the USMLE Step 1 (2024)
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- Key Vignettes for the USMLE Step 1 (2024) - PDF Handout
- Introduction to Key Vignettes (6:18)
- Creating an Illness Script (3:52)
- Problem Representation (5:22)
- Tempo of Diseases (1:50)
- HyGuru Meditation (1:39)
- Translation Defects (6:07)
- DNA Mutations (11:13)
- Robertsonian Translocation (2:21)
- I Cell Disease (3:55)
- Lipid Metabolism (6:48)
- Peroxisomal Defects (3:39)
- Glycogen Storage Disease (5:15)
- Hypoglycemia (7:45)
- Gluconeogenesis (1:58)
- ETC Pathologies (4:59)
- Vitamin Deficiencies (8:15)
- Amino Acid Derivatives (3:32)
- Malnutrition Disorders (2:59)
- Collagen Defects (3:07)
- HyGuru Meditation (0:22)
- Aging (3:30)
- Cardiovascular Disorders (4:25)
- Therapeutic Window (5:59)
- Cardiomyopathies Murmurs (10:28)
- Transudative vs. Exudative (2:36)
- Marfans Syndrome (2:23)
- Ventricular Septal Defect (1:12)
- Cardioplegia (3:08)
- Baroreceptor Firing (7:08)
- Hereditary Channelopathies (1:30)
- Thyroid Prolactin (2:28)
- Anterior Pituitary (2:38)
- Adrenal Cortex (5:26)
- Steroid Receptors (0:54)
- Aldosterone ADH (9:55)
- RAIUThyroid Hormone (7:16)
- Parathyroid Hormone (5:12)
- GI Tract Tumors (3:09)
- PPAR (2:29)
- Pelvic Anatomy (2:34)
- Twinning (2:22)
- Lymph NodeDrainage (2:10)
- Reproductive Embryology (7:15)
- Reproductive Hormones (7:36)
- Negative Feedback (1:15)
- Testicular Pathologies (3:55)
- Cardiovascular Arrows (4:26)
- Menopause Prem Ovarian Failure (2:32)
- PCOS Repro Pharm (4:42)
- Retention of Test Taking Strategies (4:05)
- HyGuru Meditation (0:35)
- Vesicoureteral Reflux (2:05)
- Renal Perfusion Physiology (4:43)
- Nephrolithiasis (2:32)
- CHF & Acid Base (1:34)
- Renal Pathology (5:18)
- Diuretic Review (3:40)
- Gastric Ligaments (2:59)
- Cirrhosis & Portal Htn (7:10)
- Dentate Line (2:48)
- HyGuru Meditation 2 (0:13)
- Diaphragmatic Defects (1:02)
- GERD (3:59)
- Eosinophilic Esophagitis (2:53)
- Hormones of the GI Tract (3:37)
- Carbohydrate Absorption (1:47)
- Gastric Duodenal Ulcers (3:38)
- Inflammatory Bowel Disease (1:42)
- IBS vs. IBD (1:26)
- Irritable Bowel Syndrome (1:11)
- Adenoma Carcinoma Sequence (4:18)
- HyGuru Meditation 3 (0:22)
- Genetic Transformation (1:55)
- Toxic Shock Syndrome (2:30)
- Type 4 HS Granuloma Formation (4:18)