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USMLE Step 1 Pass/Fail Course
Welcome to the HyGuru USMLE Step 1 Pass Fail Course
An Overview of the USMLE Step 1 Pass Fail Course (8:05)
How to Organize & Complete the Pass Fail Course
🚨 Important Disclaimer (please read)
Anki Deck (new 2026 feature! 🚨)
Download USMLE Step 1 Anki Deck | HyGuru
Course Notes
Important Info re: Course Notes 📝
USMLE Step 1 General Pathology Active Recall Review [Pathoma Ch 1-3]
General Pathology Section 🔬(2 days study schedule)
General Pathology Active Recall Review [Pathoma Ch 1-3] - PDF Handout
General Pathology (Pathoma Ch 1-3) Webinar Handout
Cell Injury, Death, and Adaptations (38:52)
Necrosis (11:29)
Apoptosis (9:05)
Free Radical Injury and Amyloid (11:34)
Acute Inflammation (24:16)
Chronic Inflammation (7:15)
Immunodeficiency (3:52)
Neoplasia (12:15)
Grading vs. Staging (1:26)
Closing Thoughts & Study Outline (2:52)
🌎 Practice Block #1
Top USMLE Concepts in Immunology
Immunology section (3-days study schedule)
Top USMLE Concepts in Immunology - PDF Handout
Introduction to Immunology for the USMLE (10:19)
Innate Immunity (13:29)
Mucosal Immunity (7:02)
Respiratory Immunity (7:04)
🌎 Practice Block #2
Salmonella Typhi (Micro Integration) (4:46)
Anatomic Barriers (2:45)
TLR & PAMPs (5:08)
Phagocytes (2:51)
🌎 Practice Block #3
Tuberculosis (Micro Integration) (18:46)
NK Cells (2:23)
MHC & HLA (3:03)
✚➖ selection (6:02)
MHC 1 vs. MHC 2 (9:28)
Autoimmune Diseases (2:16)
Addison’s & Aldosterone Escape (11:17)
🌎 Practice Block #4
Pernicious Anemia (2:45)
Hashimoto’s Thyroiditis (3:23)
Systemic Autoimmune Conditions (2:07)
Organ System Specific Autoimmune Conditions (15:52)
Acute Inflammation (3:50)
Edema & Inflammation (14:12)
Neutrophil Migration (5:54)
🌎 Practice Block #5
Phagocytosis & ROS burst (8:51)
Summary of Inflammation (6:19)
Complications of Acute Inflammation (2:46)
Wound Healing (7:28)
Delayed Wound Healing (6:21)
Spleen (10:11)
🌎 Practice Block #6
Splenomegaly (4:58)
Asplenia (4:09)
BM & Thymus (5:52)
Lymph Node (10:49)
🌎 Practice Block #7
Intro to Lymph Drainage (4:55)
Palpable Lymph Nodes (21:42)
Deep Lymph Nodes (10:06)
Adaptive Immune Response (5:16)
TSST Integration (4:25)
T cell Activation & Differentiation (7:49)
B cell Activation & Ig (8:14)
🌎 Practice Block #8
Immunodeficiencies (26:08)
Complement Disorders (9:41)
Introduction to Transplant Immunology (1:25)
Hyperacute Transplant Rejection (1:58)
Chronic Transplant Rejection (3:42)
Acute Transplant Rejection (1:52)
Graft Versus Host Disease (2:32)
Cytokines for the USMLE (6:06)
Eosinophilia (2:02)
Vaccines (10:37)
🌎 Practice Block #9
MHC (0:44)
COVID & Live Vaccines (4:48)
Immunoglobulins (5:56)
Key Immunology Details (1:16)
HyGuru Immunology for the USMLE: Hypersensitivity
HyGuru Immunology for the USMLE: Hypersensitivity - PDF Handout
Type 1 Hypersensitivity (12:08)
Asthma (3:59)
Pharmacology Integration (7:48)
🌎 Practice Block #10
Shock Integration (5:10)
Type 2 Hypersensitivity (15:12)
Endocrine Integration (2:59)
Hematology Integration (7:57)
Type 3 Hypersensitivity (8:08)
Type 4 Hypersensitivity (5:10)
General Pathology Integration (2:38)
🌎 Practice Block #11
Summary (0:22)
USMLE Step 1 Biochemistry & Metabolism Review
Biochemistry section 🧪3-days study schedule)
USMLE Step 1 Biochemistry & Metabolism - PDF Handout
Introduction (19:50)
Basics of Metabolism (4:28)
Enzyme Terminology (5:59)
Transamination Reactions (AST/ALT) (3:30)
Dehydrogenase Enzymes (6:27)
Overview of Metabolism for the USMLE (1:32)
Glycolysis (13:10)
Gluconeogenesis (11:50)
🌎 Practice Block #12
Metabolic Regulation of Pyruvate (1:45)
Ethanol Metabolism (3:30)
Glycogen Storage Diseases (6:59)
Fructose, Galactose, Lactose (14:18)
Lipid Metabolism & Synthesis (10:19)
Fatty Acid Oxidation (8:24)
Odd Chain FA Metabolism (7:32)
🌎 Practice Block #13
B12 Deficiency Integration (2:39)
Summary of Lipids (1:02)
Ketone Metabolism (4:59)
DKA (Integration) (6:33)
Amino Acid Metabolism (9:46)
Urea Cycle (8:23)
🌎 Practice Block #14
Collagen Synthesis (5:04)
Energy Production (9:37)
TCA Cycle (5:10)
Electron Transport Chain (20:38)
Uncoupling Agents (17:03)
Cholesterol & Lipid Metabolism (9:58)
VLDL (5:02)
IDL (2:26)
🌎 Practice Block #15
LDL & Atherosclerosis (5:30)
HDL (4:30)
Lipid Disorders for the USMLE (11:32)
HMP Shunt Pathway (9:19)
🌎 Practice Block #16
🌎 Practice Block #21
Nucleotide Synthesis (3:07)
Biochemistry of Nutrition (2:56)
Fat Soluble Vitamins (6:53)
Cystic Fibrosis (5:05)
Water Soluble Vitamins (12:27)
Approach to Pedigrees on the USMLE (15:18)
🌎 Practice Block #17
Lysosomal Storage Diseases (2:52)
Summary of Biochemical Pathways (6:11)
Chromosome Abnormalities for the USMLE (8:17)
DNA Synthesis, Transcription, Translation (USMLE Step 1)
DNA Synthesis, Transcription, Translation Handout
Session Outline (5:17)
Sites of Metabolism (3:14)
DNA Rapid Review (1:33)
HMP Shunt Nucleotide Synthesis (6:28)
DNA Replication (2:40)
Telomerase & Topoisomerase (4:44)
DNA Polymera & Synthesis (4:12)
🌎 Practice Block #18
Transcription (2:12)
Steroid hormones (8:42)
Lac Operon (4:35)
Transcription revisited (4:36)
Splicing and Post Transcriptional_Modifications (1:22)
Spinal Muscular Atrophy Integration (7:01)
Translation (1:02)
tRNA structure significance (3:30)
Prokaryotic vs Eukaryoti translation (8:08)
Protein Elongation Virulence Factor Integration (4:31)
🌎 Practice Block #19
Trnaslocation (3:16)
Post Translational Modification (4:10)
I Cell disease Integration (1:10)
Summary (0:23)
Genetic Principles & Hardy Weinberg
Genetic Terms & Pedigrees Handout
Introduction (1:43)
Overview (2:24)
Session Outline (3:17)
Multi-Organ Dysfunction (1:50)
Co Dominance (4:21)
Variable Expressivity vs Pleiotropy (1:41)
Genotype vs Phenotype (1:10)
Neurofibromatosis (7:26)
Anticipation (3:54)
USMLE Trinucleotide Repeats (4:57)
Mosaicism (1:39)
Imprinting Disorder (6:31)
Linkage Disequilibrium (5:19)
Test Taking Strategy for USMLE (5:43)
Pedigrees (6:55)
USMLE Step 1 — Metabolic and Genetic Syndromes
USMLE Step 1 — Metabolic and Genetic Syndromes - PDF Handout
Introduction (2:32)
A Test Taking Approach for Syndromes (5:28)
Down's Syndrome Integration (15:18)
Patau & Edwards Syndrome (2:39)
Imprinting Syndromes (5:01)
Homocystinuria (4:09)
Marfanoid Habitus (8:30)
Marfan’s Syndrome (1:36)
🌎 Practice Block #20
Ehler’s Danlos Syndrome (2:17)
Lesch Nyhan Syndrome (3:16)
Kartagener’s Syndrome (4:31)
Cystic Fibrosis (8:00)
Neurocutaneous Syndromes (3:00)
Lupus Integration (9:29)
High Yield Images & PE for the USMLE Step 1 (Introduction)
Course Overview (1:49)
Top Images PDF
USMLE Test Taking Strategy Approach to Multi-Media Questions (3:07)
USMLE Study Tip (0:51)
Test Taking Strategy for Image Questions (6:27)
Top Images You Will Encounter on the USMLE (40:05)
Foundations of Physiology for the USMLE (Cardiology)
Cardiology Section 🫀(4-day Study Schedule)
Foundations of Physiology for the USMLE (Cardiology) - PDF Handout
Introduction (2:48)
Cardiac Cycle (8:09)
Isovolumetric Ventricular Contraction (2:38)
Rapid Ventricular Ejection (5:42)
Isovolumetric Ventricular Relaxation (3:11)
Ventricular Filling (9:39)
Atrial Systole (5:20)
Jugular Venous Tracing (5:03)
Pulsus Paradoxes (3:25)
🌎 Practice Block #22
Pressure Volume Loops (17:00)
Cardiac Action Potentials (6:04)
Integrative Microbiology (Cardiology)
Important Microbes for Cardiology
Integrated Microbiology - Cardiology Notes (PDF)
Integrated Microbiology for the USMLE | Cardiology
Overview (10:30)
Hyperthermia (1:45)
Immunocompromised Host for USMLE (2:04)
Acute Inflammation for USMLE (5:58)
Cardiac Microbiology (2:10)
Pathophysiology of Sub-Acute Bacterial Endocarditis (0:46)
Bacteria Biofilms (3:47)
Viridans Streptococci (1:22)
Indications for Antimicrobial PPX for Endocarditis (1:11)
Acute Bacterial Endocarditis (5:38)
IV Drug Use and Endocarditis (1:51)
Culture Positive Infective Endocarditis (2:46)
Pathophysiology of Acute Rheumatic Fever (3:57)
Group A Streptococcus (3:15)
Scarlet vs Rheumatic Fever (2:38)
Jones Criteria for USMLE (3:59)
Heart Block Lyme Disease (4:14)
Mitral Stenosis (2:41)
Staph and Strep Morphology Summary (3:00)
Diphtheria (2:51)
Protein Synthesis Inhibition (2:46)
Myocarditis (1:00)
NBME Top Concepts: Cardiology
Introduction (6:38)
DiGeorge Syndrome (3:00)
Branchial Pouch Derivatives (3:50)
Lipid Lowering Drugs (14:45)
Shock (23:42)
Thermoregulation (3:12)
🌎 Practice Block #23
S3, S4, HOCOM, DCM, murmurs (8:50)
🌎 Practice Block #24
Vasculitis (4:43)
Post MI Complications (7:39)
Test Taking Strategies Masterclass (1:27)
High Yield USMLE Images & PE Findings: Cardiology
Course Overview (1:00)
Right Heart Failure vs. Left Heart Failure (5:48)
🌎 Practice Block #25
Murmurs & Maneuvers (25:15)
Transudative vs. Exudative for the USMLE (1:29)
Mechanisms of Edema (3:17)
X-Rays of Cardiac Lesions (0:29)
Turner Syndrome (2:45)
Rapid Review Genetic Heart Lesions & Cardiac Anomalies (2:02)
Genetic Conditions & Heart Lesions (0:53)
Pathophysiology of Tetralogy of Fallot (3:33)
Pathophysiology of Tet Spells (2:44)
Endocarditis (4:05)
🌎 Practice Block #26
Microbiology Integration (3:12)
Infective Endocarditis on USMLE (3:17)
Rheumatic Fever (6:09)
Erythema Marginatam (1:18)
Integrative Classroom Cases: Cardiology
Integrative Classroom Case: Septal Defects (9:21)
Integrative Classroom Case: Fetal Circulation (3:10)
Integrative Classroom Case: Murmurs (8:19)
Integrative Classroom Case: Arrhythmias (16:07)
Integrative Classroom Case: Amyloid & Carotid Hypersensitivity (2:30)
Integrative Classroom Case: Congenital Heart Defects (2:56)
Integrative Classroom Case: Dyslipidemia & Myocardial Infarction (19:45)
Integrative Classroom Case: Endocarditis, Myocarditis, Pericarditis (18:30)
Integrative Classroom Case: Chest Pain, Cardiomyopathies, & CHF (11:24)
An Introduction to Mechanisms of Pharmacology
An Introduction to Mechanisms of Pharmacology - PDF Handout
How to Approach Pharm Questions on the USMLE (15:10)
Mechanisms of Pharmacology (Cardiology)
Mechanisms of Pharmacology (Cardiology) - PDF Handout
Introduction to Cardiac Pharm (0:54)
Atrial Fibrillation & Virchow’s Triad (6:40)
Rate Control vs. Rhythm Control (3:00)
Anti-Arrhythmic Medications (Intro) (2:55)
Amiodarone Systemic Toxicity (3:09)
Cardiac Action Potentials (6:13)
Class 1 Anti-Arrhythmics (4:14)
Drug Induced Lupus Integration (2:08)
Class 2 Anti-Arrhythmics (Integrates MVO2) (7:20)
🌎 Practice Block #27
Calcium Channel Blockers (6:57)
Summary of Anti-Arrhythmics (1:22)
Introduction to Heart Failure (RAAS) (11:14)
Acute Heart Failure Pharmacology (4:05)
Chronic Heart Failure Pharmacology (3:38)
Digoxin (Toxicity) (4:50)
Anti-Lipid Agents (9:36)
LDL, HDL, TAG, Niacin (2:47)
🌎 Practice Block #28
Fat Soluble Vitamins (integration) (4:58)
Foundations of Physiology for the USMLE (Endocrine)
Endocrine Section 🍭(4-day Study Schedule)
Foundations of Physiology for the USMLE (Endocrine) - PDF Handout
Endocrine Physiology Handout (revised)
Key Concepts (0:43)
Hormone Receptor Pathways (33:09)
Thyroid Synthesis and Regulation (9:57)
Adrenal Cortex Zones (13:40)
Calcium Homeostasis (8:34)
Estrogen and Progesterone (6:59)
Integrative Microbiology (Endocrine)
Important Microbes for Endocrine
NBME Top Concepts: Endocrine
Introduction (5:53)
Lecture Preview (1:25)
Hormone Signaling (9:46)
🌎 Practice Block #29
Thyroid Disorders (7:38)
Hypothyroid (6:06)
Hyperthyroid (9:45)
PTH and Calcium (9:57)
MEN Syndromes (6:29)
Islet Cell Tumors (3:33)
DKA vs. HHS (6:27)
Diabetes Pharmacology (4:55)
🌎 Practice Block #30
Aldosterone Disorders (3:12)
Conclusion (2:12)
Endocrine: Thyroid Disorders (15:44)
Integrative Classroom Case: Adrenal Disorders (19:16)
Mechanisms of Pharmacology (Endocrine)
Mechanisms of Pharmacology (Endocrine) - PDF Handout
Approaching Diabetes Questions on the USMLE (6:11)
GLUT Receptor Review (3:24)
Diabetes Pharmacology (5:46)
Insulin Preparations (2:01)
Mechanisms of Pharmacology (ANS)
Mechanisms of Pharmacology (ANS) - PDF Handout
USMLE Step 1 Pharmacology of the Autonomic Nervous System
Toxicology for the USMLE (Antidotes)
First Aid Rapid Review for the USMLE (Cardio, Endo, ANS)
First Aid Rapid Review for the USMLE (Cardio, Endo, ANS) - PDF Handout
Cardiovascular, Endocrine, Autonomic NBME Review (69:11)
Autonomic Question Breakdown
Foundations of USMLE Physiology (Renal)
Foundations of USMLE Physiology (Renal) - PDF Handout
Introduction to USMLE Renal Physiology (5:25)
Organization of the Kidney (12:59)
Glomerular Physiology (8:39)
GFR (2:59)
RPF (6:30)
RBF and Filtration Fraction (4:31)
Practical USMLE Qs (7:31)
Regional Aspects of Nephron (19:58)
🌎 Practice Block #34
Integrative Microbiology (Renal)
Important Microbes for Renal
Integrated Microbiology - Renal Notes (PDF)
Integrated Microbiology for the USMLE | Renal
Overview of Session (0:58)
Renal Microbiology for USMLE (4:05)
Acute Cystitis (3:47)
Renal Physiology Integration (4:44)
Enterococcus for USMLE (4:05)
Acute Interstitial Nephritis (0:46)
Sterile Pyruia for USMLE (3:54)
Pathophysiology of UTI (8:19)
UTI Microbiology for USMLE (4:19)
Medications for UTI in Pregnancy (1:40)
Pregnancy Physiology Integration (4:51)
Staghorn Calculus & Kidney Stones (3:07)
Cystitis vs Pyelonephritis (3:09)
Micturition Autonomic Integration (4:16)
Urinary Tract Histology Integration (1:25)
Squamous Cell Carcinoma of Bladder (3:33)
Adenovirus for USMLE (2:50)
Prostatitis for USMLE (0:57)
Summary (3:59)
Top NBME Concepts: Renal
Introduction (2:01)
Renal Casts (10:30)
Kidney Stones (9:45)
Urea Cycle + Stones (pt. 2) (11:08)
Intro to Nephritic/Nephrotic (1:20)
Nephrotic Syndrome (12:36)
Nephritic Syndrome (11:21)
Renal Failure (4:47)
Diuretics (7:56)
🌎 Practice Block #35
Conclusion (2:30)
High Yield USMLE Images & PE Findings: Renal
Overview (0:52)
Rapid Review of Casts & Stones (25:40)
Polycystic Kidneys (19:13)
Rapid Review of Nephrotic & Nephritic Syndromes (21:30)
Tumors of the Urinary Tract (5:49)
Integrative Classroom Cases: Renal
Integrative Classroom Case: Renal Embryology (13:27)
Integrative Classroom Case: Electrolyte Disturbances (11:45)
Mechanisms of Pharmacology (Renal)
Mechanisms of Pharmacology (Renal) - PDF Handout
Nephron Physiology (integration) (7:40)
Aldosterone vs. ADH (6:07)
Renal Pharmacology (3:53)
Medications which cause HyperK (integration) (3:50)
NBME Top Concepts: Acid Base
Systematic Approach to Acid Base Qs on the USMLE (10:35)
Compensation (11:22)
Winter’s Formula (6:25)
Davenport Diagram (7:29)
High Yield NBME Style Qs (22:19)
Integrative Microbiology (Reproductive)
Important Microbes for Reproductive
Integrated Microbiology for the USMLE (Reproductive)
Integrated Microbiology for the USMLE (Reproductive) - PDF
Introduction (1:43)
Integrated Microbe Summary (1:31)
Neonatal Infections (2:20)
Neonatal Sepsis (6:53)
TORCH infections (3:19)
CMV (6:36)
Pathophysiology of Failure To Thrive (4:41)
HPV (4:47)
Koliocytosis (3:16)
Double Stranded DNA Viruses (3:31)
P53 Pathophysiology (2:42)
Sexually Transmitted Infections (5:21)
Cervicitis & Urethritis (5:02)
Chlamydia Integration (5:42)
Reactive Arthritis (2:35)
Sexually Transmitted Ulcers (7:54)
PID Complications (2:56)
Syphilis Manifestations (3:24)
Top NBME Concepts: Reproductive
Introduction (1:35)
Disorders of Sexual Development (9:22)
Turner’s Syndrome integration (9:49)
Testosterone Disorders (3:48)
Mullerian Agenesis vs. AIS (4:35)
Summary of Disorders of Sexual Development (1:07)
Polycystic Ovarian Syndrome (8:20)
Ovarian Physiology (3:06)
🌎 Practice Block #39
Ovarian Tumors (13:24)
Repro Ligaments (2:40)
Uterine Disorders (9:15)
Cervical Disorders (HPV) (2:43)
Integrative Classroom Case: Pharyngeal Arches (12:58)
Integrative Classroom Case: Menstrual Cycle (10:40)
Mechanisms of Pharmacology (Reproductive)
Mechanisms of Pharmacology (Reproductive) - PDF Handout
Selective Estrogen Receptor Modulators (1:30)
Steroid Receptor Physiology (0:40)
Tamoxifen, Raloxifene, Clomiphene (3:36)
Ovarian & Testicular Physiology [Integrated!] (5:00)
Testosterone Agents (3:26)
Foundations of USMLE Physiology (Gastrointestinal)
Gastroenterology section (4-days study schedule)
Foundations of USMLE Physiology (Gastrointestinal) - PDF Handout
Gastrointestinal Physiology Handout
Content Overview (1:00)
Gastrointestinal Hormones (20:11)
Regulation of Acid Secretion (19:44)
Digestion and Absorption (26:46)
Integrative Microbiology (Gastroenterology)
Important Microbes for Gastroenterology
Integrated Microbiology - Gastroenterology Notes (PDF)
Integrated Microbiology for the USMLE | Gastroenterology
Overview (1:13)
Ulcers on the USMLE (6:16)
Pathophysiology of H.Pylori (7:36)
Oncogenic Microbes (1:25)
Diarrhea (4:49)
Viral Diarrhea (4:20)
Protozoal Diarrhea (7:08)
Guillain Barre Syndrome (1:37)
Hemolytic Uremic Syndrome (5:19)
Bacterial Causes of Bloody Diarrhea (4:10)
Typhoidal Salmonella (0:43)
Bacterial Causes of Non-bloody Diarrhea (6:52)
Hepatitis B (14:59)
Hep B vs Hep C (5:59)
NBME Top Concepts: Gastroenterology
Introduction (7:56)
Esophageal Issues (12:00)
Acid Secretion in Stomach (10:06)
Approach to Abdominal Pain on the USMLE (10:30)
🌎 Practice Block #41
Hernias (4:23)
Meckel’s Diverticulum (4:10)
Hirschsprung’s Disease (1:59)
Inflammatory Bowel Disease (8:38)
Bile Acid Metabolism (3:40)
Hepatitis B (2:53)
Vesicular Steatosis (5:15)
🌎 Practice Block #42
Integrative Classroom Case: Peptic Ulcer Disease (6:35)
Integrative Classroom Case: GERD, Hernias, & Esophageal Disorders (8:33)
High Yield USMLE Images & PE Findings: Gastroenterology
Overview (0:16)
Oral Pathology (20:13)
Rapid Review of Esophageal Pathology (23:14)
Stomach Pathology (16:41)
🌎 Practice Block #43
Intestinal Pathology (9:11)
Mechanisms of Pharmacology (Gastrointestinal)
Mechanisms of Pharmacology (Gastrointestinal) - PDF Handout
Acid Physiology in Stomach (3:40)
Anti-Acid Medications (3:15)
Osteoporosis & C-diff (2:47)
🌎 Practice Block #44
First Aid Rapid Review for the USMLE (Renal, Reproductive, Gastro)
First Aid Rapid Review for the USMLE (Renal, Reproductive, Gastro) - PDF Handout
Rapid Review (Renal, Repro, Gastro) Handout
Renal, Reproductive, GI (89:12)
Neuroanatomy for the USMLE
Neurology section🧠 (4-days study schedule)
Neuroanatomy Notes for the USMLE (PDF)
Neuroanatomy Test Taking (3:00)
Foramina of the Skull (15:39)
Jugular Foramen (8:00)
Chiari Malformations (4:19)
Intro to Cranial Nerves (1:58)
CN 1 | Olfactory (2:07)
CN 2 | Optic (1:42)
Pupillary Reflex (2:33)
CN 3 | Oculomotor (4:41)
CN 4 | Trochlear (1:54)
CN 5 | Trigeminal (2:34)
🌎 Practice Block #45
Jaw Jerk & Corneal Reflex (2:56)
Intranuclear Ophthalmoplegia (4:43)
CN 6 | Abducens (3:26)
CN 7 | Facial (4:16)
Tongue Innervation (5:05)
CN 8 | Vestibulocochlear (5:03)
CN 9 | Glossopharyngeal (3:34)
CN 10 Vagus (7:56)
CN 11 | Spinal Accessory (2:44)
CN 12 | Hypoglossal (3:56)
Medial vs Lateral Medullary syndrome (1:21)
Pontine Strokes (4:18)
🌎 Practice Block #46
Midbrain Strokes (3:44)
Subclavian Steal (2:58)
Optic Tracts (9:34)
Eye Movements (3:18)
Intro to Spinal Tracts (0:49)
Dorsal Column (3:00)
Corticospinal Tract (2:34)
Spinothalamic Tract (2:53)
Brown Sequard (2:45)
Spinal Cord Lesions (8:09)
🌎 Practice Block #47
Parkinson’s Disease (4:05)
Alzheimer’s Disease (7:02)
Summary of Neurotransmitters (2:32)
Neural Tube & Brain Embryo (7:06)
🌎 Practice Block #48
Hydrocephalus & Tumours (2:04)
Gait Disorders (2:57)
🌎 Practice Block #49
Hemiballismus (1:24)
Deep Brain Strokes (9:01)
Stroke Integration (9:44)
Conclusion (1:58)
Integrative Microbiology (Neurology)
Important Microbes for Neurology
Integrated Microbiology - Neurology Notes (PDF)
Integrated Microbiology for the USMLE | Neurology
Introduction (4:13)
Meningitis (8:31)
Mechanisms of Bacterial CNS Infections (3:43)
Temporal Lobe Abscess (7:51)
Brain Abscess due to Infective Endocarditis (0:53)
Neisseria Transmission (2:16)
Waterhouse Friedrichsen Syndrome (4:53)
Cyptoccal Infections (7:45)
Summary of Bacterial Meningitis (6:18)
Measles (1:06)
Arbovirus (2:55)
Echovirus (2:05)
Coxsackie A (3:53)
Ring Enhancin Brain Lesions for the USMLE (1:20)
TORCH Infections for the USMLE (2:52)
Pharmacology Integration (1:50)
Prions (2:32)
Summary (0:53)
NBME Top Concepts: Neurology
Introduction (2:06)
Brain Hematomas (12:05)
Herniation Syndromes & Cerebral Physiology (10:42)
Cranial Nerve Path (1) (8:45)
Bell’s Palsy (5:43)
Cranial Nerve Path (2) (3:11)
Multiple Sclerosis (5:22)
🌎 Practice Block #50
Dementia (6:33)
Dopamine Pathways (1:59)
Trinucleotide Repeat Disorders (3:01)
Neurocutaneous Syndromes (4:55)
Brain Tumors (4:25)
🌎 Practice Block #51
Stroke (6:40)
🌎 Practice Block #52
Conclusion (3:32)
Integrative Classroom Case: Cranial Nerves (7:22)
Integrative Classroom Case: Aneurysms (8:21)
High Yield Images & PE Findings: Neurology
Overview (1:25)
Neuroanatomy (1:43)
Rapid Review of Trinucleotide Repeat Disorders (4:52)
Pituitary Masses (1:53)
Thalamic Stroke (2:32)
Central Pontine Myelinolysis (4:36)
Internal Capsule and Lacunar Strokes (5:26)
Rapid Review of Multiple Sclerosis (3:04)
Cerebral Edema (3:04)
🌎 Practice Block #53
Intracranial Pressure (2:23)
Rapid Review of Cerebral Autoregulation (2:25)
Baroreceptor Reflex (7:43)
Upper Motor Neuron Signs & Posturing (0:11)
Spinal Cord Pathologies (12:07)
Pseudotumor Cerebri (3:33)
Hydrocephalus (5:47)
CNS Infections (3:36)
🌎 Practice Block #54
Pharmacology of the Nervous System
Pharmacology of the Nervous System - PDF Handout
Introduction (0:18)
Anesthesia (20:37)
Cerebral Autoregulation (Anesthesia) (6:00)
GABA Drugs (5:20)
Parkinson’s vs Alzheimer’s (2:44)
Basal Ganglia Neuro-Anatomy integration (4:24)
Parkinsonian Pharmacology [Dopamine] (9:20)
Alzeihmer’s Drugs (7:26)
NMDA Integration for the USMLE (1:26)
Autonomic Pharmacology Integration (Ach) (2:54)
AchE for Myasthenia Gravis (2:23)
100 Concepts in Gross Anatomy for the USMLE Step 1
100 Concepts in Gross Anatomy for the USMLE Step 1 - PDF Handout
USMLE Musculoskeletal Review
100 Concepts PDF
Integrative Microbiology (MSK)
MSK & Dermatology section🧏🏻♀️(2-days study schedule)
Important Microbes for MSK
Top NBME Concepts: Dermatology
Overview (3:36)
Approach to Urticaria (8:37)
Dermatology Nomenclature (4:45)
Plaques (3:51)
Viral & Bacterial Exanthems (7:21)
Rubella (3:01)
Measles (2:39)
Roseola (0:31)
Erythema Infectiosum (5:05)
Systemic Manifestations of Herpes (3:10)
Varicella Infections on USMLE (2:00)
Erysipelas vs Cellulitis (1:29)
Staph and Strep Infections (2:57)
Nikolsky Sign Manifestations for the USMLE (3:36)
Neonatal Rashes (2:34)
Precursor Lesions to Neoplasia (3:17)
🌎 Practice Block #57
Summary (2:19)
Top NBME Concepts: Rheumatology
Introduction (2:45)
NMJ Disorders (9:56)
Bullous Diseases (5:33)
Hemoptysis & Hematuria (7:34)
Skin Cancers (with Neural Crest) (19:50)
RA vs OA (12:49)
🌎 Practice Block #58
Seronegative Spondyloarthritis (7:28)
Lupus (8:03)
Anti Body Rapid Fire (USMLE) (8:34)
Integrative Classroom Case: Introduction to Dermatological Principles (6:22)
Integrative Classroom Case: Fungal Rashes (7:49)
Integrative Classroom Case: Collagen Disorders & Synthesis (7:02)
Integrative Classroom Case: Bone Disorders
Top NBME Concepts: Psychiatry
Introduction (2:06)
Mood Disorders (15:39)
Bipolar + Li Pharm (9:16)
🌎 Practice Block #59
Psychotic Disorders (12:41)
Eating Disorders (8:16)
Drugs of Abuse (Toxicology) (12:36)
Psychopharmacology
Psychopharmacology - PDF Handout
Introduction to Psychosis (2:08)
Dopaminergic Pathways for the USMLE (1:29)
Anti-Psychotics (3:08)
Neuroleptic Malignant Syndrome (2:25)
MH vs. NMS vs. SS [integration] (1:57)
1st Generation Antipsychotics (6:53)
Rapid Review (1st generation) (1:46)
2nd Generation Anti-Psychotics (4:37)
Agranulocytosis Medications (1:45)
Anti-Depressants (Introduction) (2:21)
Serotonin Syndrome (3:31)
Anti-Depressants (Typical & Atypicals) (8:40)
Tricyclic Anti-Depressants (5:00)
First Aid Rapid Review for the USMLE (Neuro, MSK, Derm, Rheum, Psych)
Rapid Review (Neuro, MSK, Derm, Rheum, Psych) - PDF Handout
Rapid Review (Neuro, MSK, Derm, Rheum, Psych) Handout
Neurology, Musculoskeletal, Dermatology, Rheumatology, Psychiatry (82:53)
Foundations of Physiology (Hematology)
Hematology section🩸(4-days study schedule)
Foundations of Physiology (Hematology) - PDF Handout
Key Concepts for Heme Physiology (1:05)
Blood Composition Overview Concept (1:42)
Fetal Erythropoiesis (10:45)
Haemoglobin Physiology (30:26)
Components of Blood (20:01)
Summary and CBC Interpretation for the USMLE (0:52)
Integrative Microbiology (Hematology)
Important Microbes for Hematology
NBME Top Concepts: Hematology
Introduction (7:52)
Lecture Preview (1:05)
Heme Synthesis (5:40)
CYP Inducers (3:47)
🌎 Practice Block #64
Lead Poisoning (3:01)
Approach to the Blood Smear (8:32)
Intro to Anemia (3:07)
Microcytic Anemia (5:01)
Acute Phase Reactants (1:41)
Summary of Microcytic (2:00)
Macrocytic Anemia (5:14)
B12 Physiology (1:30)
🌎 Practice Block #65
Normocytic Anemia (6:58)
HUS/TTP (2:57)
Polycythemia (2:56)
Platelet Pathology (5:33)
🌎 Practice Block #66
Warfarin vs. Heparin (2:35)
Multiple Myeloma (2:42)
Summary & Courses (2:14)
Integrative Classroom Case: Sickle Cell Disease (4:49)
Neurology: Stroke (19:22)
High Yield Images & PE Findings: Hematology
Hematology Overview (2:14)
Peripheral Blood Smear (8:47)
RBC Inclusions (9:48)
🌎 Practice Block #67
Sickle Cell Disease (12:33)
Complications of Asplenia (3:44)
Summary of RBC Inclusions (3:25)
Mechanisms of Extravascular RBC Hemolysis (1:39)
Mechanisms of Intravascular RBC Hemolysis (2:11)
Rapid Review of Normocytic Anemia (7:45)
Aplastic Anemia (11:40)
Cold and Warm AIHA (0:51)
HUS/TTP (1:42)
Cells of the Immune System (2:17)
Causes of Eosinophilia on USMLE (0:58)
Causes of Plasma Cells on USMLE (2:33)
Causes of Mast Cells on USMLE (2:22)
Mechanisms of Pharmacology (Hematology)
Mechanisms of Pharmacology (Hematology) - PDF Handout
Hypercoagulable Pathology (integration) (5:12)
Anti-coagulants (overview) (0:44)
Primary Hemostasis Pharmacology (8:54)
Secondary Hemostasis Pharmacology (Heparin vs. Warfarin) (3:47)
Heparin Induced Thrombocytopenia (2:02)
Direct Factor Inhibitors (4:06)
Foundations of Physiology (Respiratory)
Respiratory section 🫁(4-days study schedule)
Foundations of Physiology (Respiratory) - PDF Handout
Content Overview (1:31)
Lung Volumes and Spirometry (20:27)
VQ Distribution (19:37)
Central Regulation of Breathing (6:31)
Ventilation (15:46)
Summary (0:53)
Integrative Microbiology (Respiratory)
Important Microbes for Respiratory
Integrated Microbiology - Respiratory Notes (PDF)
Integrative Microbiology for the USMLE (Respiratory)
Upper Respiratory Tract Disease (8:00)
Influenza for the USMLE (7:43)
Sinusitis for the USMLE (3:47)
Pharyngeal Disease (5:47)
Laryngotracheitis (3:03)
Coxsackie AB is Picorna (PERCH) (7:38)
Epiglottis for the USMLE (6:27)
Pertussis for the USMLE (1:28)
Lower RespiratoryTract Disease (3:32)
Anatomic Distributions of PNA (2:20)
Think Like a Test Maker (1:56)
Bronchopneumonia (2:22)
Mycoplasma for USMLE (8:11)
Respiratory Microbes for the USMLE (2:26)
S. Pneumoniae for the USMLE (3:44)
Pathogenesis of TB (2:30)
Recurrent Pneumonia for the USMLE (3:00)
Pneumocystis for the USMLE (1:44)
Top NBME Concepts: Respiratory
Introduction (2:36)
A-a gradient (hypoxemia) (23:45)
Regional Circulation for the USMLE (11:43)
Physical Exam MCQs (Resp) (9:03)
Restrictive vs Obstructive Lung Disease (13:06)
Lung Tumors (6:06)
Acute Respiratory Distress Syndrome (6:12)
🌎 Practice Block #72
Conclusion (0:23)
Integrative Classroom Case: Hypoxemia (5:08)
Integrative Classroom Case: Restrictive Lung Diseases & Pneumoconiosis (8:11)
Integrative Classroom Case: Obstructive Lung Diseases (19:27)
High Yield USMLE Images & PE Findings: Respiratory
Overview (13:33)
Pneumothorax (13:16)
Pneumonia for the USMLE (19:41)
Clubbing (2:26)
Acute Respiratory Distress Syndrome (6:55)
Mechanisms of Pharmacology (Respiratory)
Mechanisms of Pharmacology (Respiratory) - PDF Handout
Introduction (0:24)
Pathophysiology of Asthma (4:36)
β-Agonists (10:03)
Systemic Toxicities of Corticosteroids (4:42)
Anti-Leukotrienes & AA Pathway (1:50)
Asthma Adjuncts (1:21)
Pulmonary Hypertension Pathophysiology (6:18)
Pulmonary Hypertension Pharmacology (2:22)
Anti-Allergic Pharmacology (2:59)
First Aid Rapid Review for the USMLE (Heme, Resp, Embryo)
First Aid Rapid Review for the USMLE (Heme, Resp, Embryo) - PDF Handout
Rapid Review (Heme, Resp, Embryo) Handout
Hematology, Respiratory, Pharyngeal Arches (68:37)
Integrative Microbiology (Oncology)
Important Microbes for Oncology
Top NBME Concepts: Oncology
Oncology section🎗️(2-days study schedule)
Introduction to Oncology (0:56)
Cardiac Oncology (5:38)
Endocrine Oncology (9:03)
Gastrointestinal Oncology (20:42)
🌎 Practice Block #76
Lymphoma (10:06)
Vascular Tumors (3:46)
Renal Oncology (10:39)
🌎 Practice Block #77
Respiratory Oncology (5:33)
Neuro-Oncology (6:46)
Breast Oncology (8:34)
🌎 Practice Block #78
Gen Path Integration: Neoplasia (2:36)
Chemotherapeutics & Immunologics
Chemotherapeutics & Immunologics - PDF Handout
Cell Cycle Agents (4:31)
Microtubule Integration (1:14)
G1 Inhibitors (4:18)
Nucleotide Synthesis (3:28)
Monoclonal Ab (3:55)
Anti Microbials
Microbiology section 🦠(2-days study schedule)
Anti Microbials - PDF Handout
Antibiotics PDF
Beta-Lactam Introduction (9:22)
Penicillins (6:43)
Beta-Lactamase Sensitive Penicillin (12:21)
Beta-Lactamase Resistant Penicillin (5:16)
Antipseudomonal Penicillins (5:23)
Key Bacterial Virulence Mechanisms (5:33)
Cephalosporins (7:09)
Broad Spectrum Antibiotics (4:30)
Rapid Review (1:02)
30S Ribosomal Subunit Antibiotics (5:43)
50S Ribosomal Subunit Antibiotics (6:24)
Resistance Mechanisms & Conclusion (5:18)
Integrative Microbiology (Zoonotic)
Important Microbes for Zoonology
USMLE Ethics, PBLI, Patient Safety & Physician Communication
USMLE Ethics, PBLI, Patient Safety & Physician Communication - PDF Handout
Ethics, PBLI, Patient Safety & Physician Communication Handout
Introduction to Ethics (5:36)
Core Ethical Principles (48:37)
Public Health Sciences (16:00)
Nosocomial Infections (8:50)
Patient Safety (18:02)
Physician Communication (4:43)
High Yield Arrows for the USMLE ⬆️ ⬇️
High yield arrows section ⬆️ ⬇️(2-days study schedule)
High Yield Arrows for the USMLE - PDF Handout
Overview of Arrow Questions (3:54)
Cardiology System (1:23)
Baroreceptor Reflex (7:51)
Edema (2:36)
Aldosterone Escape (3:04)
Ventricular Septal Defect (3:05)
Respiratory System (1:09)
Chronic Respiratory Acidosis (3:10)
Hypoxemia (5:10)
Aging (1:36)
Neonatal ARDS (2:05)
Endocrine System (1:19)
Adrenal Insufficiency (5:18)
Waterhouse Friderichsen Syndrome (1:45)
Hyperthyroidism (4:37)
Euthyroid Sick Syndrome (1:49)
Thyroid Binding Globulin (2:10)
PTH effects on Bone Kidney and Intestine (4:40)
Tertiary Hyper PTH (2:27)
Albrights for the USMLE (4:23)
Vitamin D Metabolism (2:38)
Paget Diseases for USMLE (1:55)
Reproductive System (1:04)
Two Cell Hypothesis (7:08)
Renal System (3:24)
Nephron Key Features (9:14)
Afferent vs Efferent Arteriole (2:56)
Renin Angiotensin Aldosterone System (1:59)
Primary vs Secondary Hemostasis (3:50)
Integrated Embryology for the USMLE Step 1
Embrology section 👶(2-days study schedule)
Introduction (4:45)
Session Outline (2:24)
Neural Tube Defects (2:48)
Potter Sequence (2:41)
Amniotic Fluid Integration (2:41)
Trilaminar Structure Derivation (6:28)
GI Embryology & Histology Integration (4:35)
Neural Crest Derivatives (6:55)
DiGeorge Syndrome (5:22)
Genital Organ Differentiation (4:52)
Atresia for the USMLE (5:43)
Umbilical Cord Embryology (3:06)
Renal Embryology (5:12)
ENT Embryology (4:41)
Embryology Rapid Review (3:25)
Key Vignettes for the USMLE Step 1 (updated Nov 2025) 🔥
Key Vignettes for the USMLE Step 1 (2024) - PDF Handout
Introduction to Key Vignettes (6:18)
Creating an Illness Script (3:52)
Problem Representation (5:22)
Tempo of Diseases (1:50)
HyGuru Meditation (1:39)
Translation Defects (6:07)
DNA Mutations (11:13)
Robertsonian Translocation (2:21)
I Cell Disease (3:55)
Lipid Metabolism (6:48)
Peroxisomal Defects (3:39)
Glycogen Storage Disease (5:15)
Hypoglycemia (7:45)
Gluconeogenesis (1:58)
ETC Pathologies (4:59)
Vitamin Deficiencies (8:15)
Amino Acid Derivatives (3:32)
Malnutrition Disorders (2:59)
Collagen Defects (3:07)
HyGuru Meditation (0:22)
Aging (3:30)
Cardiovascular Disorders (4:25)
Therapeutic Window (5:59)
Cardiomyopathies Murmurs (10:28)
Transudative vs. Exudative (2:36)
Marfans Syndrome (2:23)
Ventricular Septal Defect (1:12)
Cardioplegia (3:08)
Baroreceptor Firing (7:08)
Hereditary Channelopathies (1:30)
Thyroid Prolactin (2:28)
Anterior Pituitary (2:38)
Adrenal Cortex (5:26)
Steroid Receptors (0:54)
Aldosterone ADH (9:55)
RAIUThyroid Hormone (7:16)
Parathyroid Hormone (5:12)
GI Tract Tumors (3:09)
PPAR (2:29)
Pelvic Anatomy (2:34)
Twinning (2:22)
Lymph NodeDrainage (2:10)
Reproductive Embryology (7:15)
Reproductive Hormones (7:36)
Negative Feedback (1:15)
Testicular Pathologies (3:55)
Cardiovascular Arrows (4:26)
Menopause Prem Ovarian Failure (2:32)
PCOS Repro Pharm (4:42)
Retention of Test Taking Strategies (4:05)
HyGuru Meditation (0:35)
Vesicoureteral Reflux (2:05)
Renal Perfusion Physiology (4:43)
Nephrolithiasis (2:32)
CHF & Acid Base (1:34)
Renal Pathology (5:18)
Diuretic Review (3:40)
Gastric Ligaments (2:59)
Cirrhosis & Portal Htn (7:10)
Dentate Line (2:48)
HyGuru Meditation 2 (0:13)
Diaphragmatic Defects (1:02)
GERD (3:59)
Eosinophilic Esophagitis (2:53)
Hormones of the GI Tract (3:37)
Carbohydrate Absorption (1:47)
Gastric Duodenal Ulcers (3:38)
Inflammatory Bowel Disease (1:42)
IBS vs. IBD (1:26)
Irritable Bowel Syndrome (1:11)
Adenoma Carcinoma Sequence (4:18)
HyGuru Meditation 3 (0:22)
Genetic Transformation (1:55)
Toxic Shock Syndrome (2:30)
Type 4 HS Granuloma Formation (4:18)
Neisserial Infections (2:40)
HIV Viral Co-Receptors (5:52)
Immunodeficiency (5:48)
Microbiology Rapid Review (10:12)
Antibiotic Rapid Review Resistance (5:58)
Immunosuppressants (3:09)
HyGuru Meditation 4 (0:20)
Myasthenia Gravis (1:08)
Chiari Malformations (5:21)
Neuroanatomy Integrations (14:35)
Neuropharmacology (9:27)
Muscle Contraction (7:28)
HyGuru Meditation 5 (0:31)
Musculoskeletal Rapid Review (9:46)
Hip Muscle Review (4:56)
Osteos for the USMLE (4:19)
Childhood Ortho for the USMLE (1:52)
Gout (1:31)
Vasculitis ANCA (3:46)
HyGuru Meditation 6 (0:21)
Pityriasis Rosea (1:01)
Nevus Lesions (1:48)
Precursor Skin Lesions (1:56)
Cellular Junction Integrations (5:17)
MSK Pharmacology Rapid_Review (4:07)
Red vs. Pale_Infarct (2:15)
O2 Content in Blood (2:52)
Vocal Cord Anatomy (2:36)
Restrictive vs. Obstructive Lung Disease (4:14)
nRDS vs. ARDS (3:15)
Mechanical Ventilator Cardiovascular Hemodynamics (6:59)
Cytomegalovirus (0:49)
Psammoma Bodies (1:34)
Lung Carcinoma (3:08)
Respiratory Pharmacology Rapid Review (1:25)
HyGuru Meditation (1:21)
Porphyria Pathologies (1:59)
Primary Hemostasis (3:54)
Lead Poisoning (1:34)
Aplastic Anemia (Thalassemia) (2:01)
Inflammation & Anemia (1:38)
Intravascular Hemolysis (4:51)
HUS vs. DIC vs. TTP (4:34)
Myeloid Neoplasms (3:41)
Congenital Neutropenia (1:00)
Plasma Cell Dyscrasia (3:57)
Bortezumib (1:35)
Non-Hodgkin’s Lymphoma (1:57)
Personality Disorders (0:58)
Approach to Ingestions (3:21)
Psychopharmacology Rapid Review (2:17)
Key Vignettes Outro (1:08)
Course Outro
Course Conclusion & Tips for Peak Performance (6:31)
How to Organize & Complete the Pass Fail Course
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Updated:
November 2025
Schedule based on 1x speed of lectures. Please note it does not take into account the time it takes to do the focused UW questions at the end of each video.
Questions?
rahul@hyguru.com
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